I'm trying to think of the route that has the billboards that read "we bear it all"???
My fondest ride is Key Largo to Key West during sunrise
My vote goes to route 98 from Ochlockonee Bay to Pensacola.
Route 1 goes almost the entire length of Florida on the east coast side of the state. Its four lane, but a 'comfortable' four lane. It reminds me of Florida's version of Route 66...with those quirky small town sites you come across...and Route 1 has those and then some!